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2015’s Major Advances in Prostate Cancer Care

One of the most frequent questions I hear in my clinic is, “Are we making any progress?” or, “Is there anything new out there?” The answer is always yes, or more properly, YES!

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Olaparib for Resistant Prostate Cancer

In what is the first (and hopefully one of many) example of using modern genomic methods to match treatments to the molecular defects in prostate cancer, the U.S. FDA has just granted “breakthrough...

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ASCO16: Precision Medicine and AR-V7

Much of the news this week in prostate cancer will be generated by the ASCO Annual Meeting in Chicago. There are likely to be considerable news releases regarding precision medicine, and especially...

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Immune Therapy for Prostate Cancer

For prostate cancer, there are both challenges and some early positive results from immunotherapy trials that remain intriguing. One of the key challenges is identifying those patients who will benefit...

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The PSA Clock

I cannot count the number of times I have thought to myself, “If it were not for the PSA, you would no doubt be out there playing golf, skiing, biking, taking a grandchild to the park, or just enjoying...

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A Perfect Death

Some reflections on John McCain, mortality, Hamilton, and the story you leave behind. 

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But Doc, What Is My Prognosis?

Regardless of prognosis, we all must live with the reality that time is fleeting, and none of us have unlimited tomorrows.

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Androgen Deprivation Therapy and Alzheimer’s Disease: Risk/Benefit

A recent study on the risk of Alzheimer's disease or dementia following the use of ADT was disturbing to me on two levels.

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Prostate Cancer, Androgen Deprivation Therapy, and COVID-19

The TMPRSS2 protein has a role in both COVID-19 and in prostate cancer, suggesting intriguing avenues of inquiry for researchers engaged in the fight against COVID-19.

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Personalized Medicine and the 529 Option

Some of my patients with advanced disease must choose between two options: an expensive novel therapy with limited benefit or palliative care and hospice. What if there was a third way?

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